Thiamine hydrochloride is a sterile solution used for injection, administered either intramuscularly (i.m.) or intravenously (i.v.) after proper dilution. Each milliliter contains 100 mg of thiamine HCl. Thiamine HCl is highly soluble in water, making it suitable for IV drip or IV infusion drip for effective administration in patients with thiamine deficiency.
Clinical Pharmacology:
Thiamine is distributed in all tissues, with the highest concentrations in the liver, brain, kidneys, and heart. It forms thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism, and helps in the decarboxylation of pyruvic acid and ketoacids, producing energy for the brain. In cases of thiamine deficiency, administering thiamine via an IV drip ensures rapid absorption and recovery.
Indications and Usage:
Thiamine is a coenzyme involved in oxidative decarboxylation reactions, essential for energy metabolism. It plays a significant role in preventing conditions such as beriberi and Wernicke-Korsakoff syndrome. Thiamine may be administered through an IV infusion drip in emergencies, such as wet beriberi with myocardial failure, to ensure rapid delivery to tissues.
Contraindications:
Thiamine administration is contraindicated in patients with known hypersensitivity to thiamine or any of the solution’s ingredients.
Warnings:
An IV infusion drip of thiamine should be monitored in such patients to prevent central nervous system and bone toxicity. Hypersensitivity or anaphylactic reactions may occur with thiamine administration.
Adverse Reactions:
Hypersensitivity reactions, including life-threatening anaphylaxis, may occur after repeated administration of thiamine. Patients receiving thiamine via IV drip should be monitored for any adverse reactions.
Overdosage:
Doses of 100-500 mg of thiamine have been administered parenterally without toxic effects. However, excessive doses are not efficiently utilized by the body.
How Supplied:
Thiamine hydrochloride is supplied in 100 mg/mL vials and in B-complex formulations with thiamine hydrochloride, 100 mg/mL.