Low-dose intravenous vitamin C (IVC) refers to doses below 15 grams. IVC doses of 15 grams and above can cause false positives on finger-stick blood glucose tests, but laboratory tests using the hexokinase serum glucose method remain unaffected. IV drip administration of up to 25 grams of IVC has shown no adverse effects or hemolysis in patients with G6PD deficiency.
Description:
L-Ascorbic acid (vitamin C) is a vital micronutrient that plays a key role in preventing scurvy and supporting various metabolic processes. While vitamin C is essential for many basic physiological functions, large doses may be beneficial for treating infections. Vitamin C is synthesized from glucose in most non-human mammals and can be delivered via an IV drip or IV infusion drip to ensure optimal therapeutic levels.
Clinical Pharmacology:
Ascorbic acid is oxidized to dehydroascorbic acid in the body and participates in critical oxidation-reduction reactions. Vitamin C is necessary for collagen production, folic acid conversion, iron metabolism, and immune function. It acts as an antioxidant, neutralizing free radicals and reducing inflammation. When administered through an IV infusion drip, vitamin C can support immune defense and protect cells from oxidative damage.
- Collagen Production: Vitamin C is an essential cofactor in collagen synthesis, promoting wound healing and vascular integrity.
- Antioxidant and Anti-inflammatory: As an antioxidant, vitamin C donates electrons to neutralize free radicals, helping reduce inflammation and oxidative stress.
- Immune Function: Vitamin C boosts the function of neutrophils, lymphocytes, and phagocytes, enhancing the body’s immune defense. Administering vitamin C via IV infusion drip supports these immune processes.
Contraindications/Warnings/Precautions:
High doses of vitamin C should be used cautiously in patients with oxalate kidney stones or hyperoxaluria. Patients with renal failure should avoid high-dose vitamin C, as it may exacerbate renal complications. Vitamin C delivered via IV drip should be carefully monitored in these patients.
Adverse Reactions:
Patients with G6PD deficiency may experience hemolysis after high-dose vitamin C infusion. Patients with iron overload or hemoglobin S disease should avoid high-dose vitamin C, especially when administered via IV drip.
Overdosage:
High doses of vitamin C are generally well tolerated. However, doses of 30-50 grams or higher should be carefully monitored, especially in patients with renal issues, to prevent dehydration or other complications.